A leaky mutation in CD3D differentially affects αβ and γδ T cells and leads to a Tαβ(–)Tγδ(+)B(+)NK(+) human SCID

T cells recognize antigens via their cell surface TCR and are classified as either αβ or γδ depending on the variable chains in their TCR, α and β or γ and δ, respectively. Both αβ and γδ TCRs also contain several invariant chains, including CD3δ, which support surface TCR expression and transduce t...

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Detalhes bibliográficos
Main Authors: Gil, Juana, Busto, Elena M., Garcillán, Beatriz, Chean, Carmen, García-Rodríguez, Maria Cruz, Díaz-Alderete, Andrea, Navarro, Joaquín, Reiné, Jesús, Mencía, Angeles, Gurbindo, Dolores, Beléndez, Cristina, Gordillo, Isabel, Duchniewicz, Marlena, Höhne, Kerstin, García-Sánchez, Félix, Fernández-Cruz, Eduardo, López-Granados, Eduardo, Schamel, Wolfgang W.A., Moreno-Pelayo, Miguel A., Recio, María J., Regueiro, José R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195454/
https://ncbi.nlm.nih.gov/pubmed/21926461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44254
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