Effects of Kynurenine Pathway Inhibition on NAD(+) Metabolism and Cell Viability in Human Primary Astrocytes and Neurons

The kynurenine pathway (KP) is the principle route of L-Tryptophan (TRP) metabolism, producing several neurotoxic and neuroprotective metabolic precursors before complete oxidation to the essential pyridine nucleotide nicotinamide adenine dinucleotide (NAD(+)). KP inhibition may prove therapeutic in...

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Bibliographic Details
Main Authors: Braidy, Nady, Guillemin, Gilles J., Grant, Ross
Format: Artigo
Language:Inglês
Published: Libertas Academica 2011
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195218/
https://ncbi.nlm.nih.gov/pubmed/22084601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/IJTR.S7052
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