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Mutation of Glutamine to Arginine at Position 548 of IE2 86 in Human Cytomegalovirus Leads to Decreased Expression of IE2 40, IE2 60, UL83, and UL84 and Increased Transcription of US8-9 and US29-32

The IE2 86 protein of human cytomegalovirus (HCMV) is essential for productive infection. The mutation of glutamine to arginine at position 548 of IE2 86 causes the virus to grow both slowly and to very low titers, making it difficult to study this mutant via infection. In this study, Q548R IE2 86 H...

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Autori principali: Burgdorf, Sarah W., Clark, Charles L., Burgdorf, James R., Spector, Deborah H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194931/
https://ncbi.nlm.nih.gov/pubmed/21865379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05315-11
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