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On the molecular basis of transition mutations: frequencies of forming 2-aminopurine.cytosine and adenine.cytosine base mispairs in vitro.

We address the question of whether substituting 2-aminopurine (APur) in place of adenine (Ade) in DNA can increase the frequency of base mispairing with cytosine. Using DNA polymerase alpha to measure the rates of inserting deoxycytidine and thymidine nucleotides in direct competition with each othe...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Watanabe, S M, Goodman, M F
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319459/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6942407/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.5.2864
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