Detection of KIAA1549-BRAF Fusion Transcripts in Formalin-Fixed Paraffin-Embedded Pediatric Low-Grade Gliomas

Alterations of BRAF are the most common known genetic aberrations in pediatric gliomas. They frequently are found in pilocytic astrocytomas, where genomic duplications involving BRAF and the poorly characterized gene KIAA1549 create fusion proteins with constitutive B-Raf kinase activity. BRAF V600E...

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Main Authors: Tian, Yongji, Rich, Benjamin E., Vena, Natalie, Craig, Justin M., MacConaill, Laura E., Rajaram, Veena, Goldman, Stewart, Taha, Hala, Mahmoud, Madeha, Ozek, Memet, Sav, Aydin, Longtine, Janina A., Lindeman, Neal I., Garraway, Levi A., Ligon, Azra H., Stiles, Charles D., Santagata, Sandro, Chan, Jennifer A., Kieran, Mark W., Ligon, Keith L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2011
Teme:
Regular Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194058/
https://ncbi.nlm.nih.gov/pubmed/21884820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2011.07.002
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