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Herpes simplex virus (type 1) thymidine kinase gene does not transform cells morphologically.

BALB/c-derived 10E2 cells were made thymidine kinase(TK)-negative and one isolated clone (B2) was used for studying morphological and biochemical transformations by herpes simplex virus (HSV) type 1 (strain 10412). The B2 cells displayed a "normal" flat appearance and were nontumorigenic in nude mic...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hampar, B, Derge, J G, Boyd, A L, Tainsky, M A, Showalter, S D
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319400/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6264486/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.4.2616
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