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Lysine methylation of promoter-bound transcription factors and relevance to cancer

p53, NFκB, STAT3, and several other transcription factors are reversibly methylated on lysine residues by enzymes that also modify histones. The methylations of NFκB and STAT3 take place when they are bound to promoters, suggesting a more general model in which the binding of inducible transcription...

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Detalhes bibliográficos
Main Authors: Stark, George R, Wang, Yuxin, Lu, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193425/
https://ncbi.nlm.nih.gov/pubmed/21151202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2010.174
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