Identification of receptors for phorbol ester tumor promoters in intact mammalian cells and of an inhibitor of receptor binding in biologic fluids.

Utilizing [3H]phorbol dibutyrate [P(Bu)2], we have developed an assay for high-affinity phorbol ester receptors in intact rat embryo fibroblasts. At 37 degrees C, binding of [3H]P(Bu)2 reached a maximum within 10 min and was rapidly reversible. The tumor promoters 12-O-tetradecanoyl-phorbol 13-aceta...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Horowitz, A D, Greenebaum, E, Weinstein, I B
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1981
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319336/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6941290/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.4.2315
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