Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia.

The WHHL (Watanabe heritable hyperlipidemic) rabbit has been proposed as an animal model for human familial hypercholesterolemia. Homozygous WHHL rabbits have marked increases in the plasma level of low density lipoprotein (LDL), removal of LDL from their plasma is delayed, and LDL receptors are abs...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Kita, T, Brown, M S, Watanabe, Y, Goldstein, J L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1981
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319326/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6264472/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.4.2268
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