A Novel Core Genome-Encoded Superantigen Contributes to Lethality of Community-Associated MRSA Necrotizing Pneumonia

Bacterial superantigens (SAg) stimulate T-cell hyper-activation resulting in immune modulation and severe systemic illnesses such as Staphylococcus aureus toxic shock syndrome. However, all known S. aureus SAgs are encoded by mobile genetic elements and are made by only a proportion of strains. Here...

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Main Authors: Wilson, Gillian J., Seo, Keun Seok, Cartwright, Robyn A., Connelley, Timothy, Chuang-Smith, Olivia N., Merriman, Joseph A., Guinane, Caitriona M., Park, Joo Youn, Bohach, Gregory A., Schlievert, Patrick M., Morrison, W. Ivan, Fitzgerald, J. Ross
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192841/
https://ncbi.nlm.nih.gov/pubmed/22022262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002271
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