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Preventing Dangerous Nonsense: Selection for Robustness to Transcriptional Error in Human Genes

Nonsense Mediated Decay (NMD) degrades transcripts that contain a premature STOP codon resulting from mistranscription or missplicing. However NMD's surveillance of gene expression varies in efficiency both among and within human genes. Previous work has shown that the intron content of human g...

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Detalhes bibliográficos
Main Authors: Cusack, Brian P., Arndt, Peter F., Duret, Laurent, Crollius, Hugues Roest
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192821/
https://ncbi.nlm.nih.gov/pubmed/22022272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002276
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