Intra- and Inter-clade Cross-reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials

The genetic diversity of HIV-1 across the globe is a major challenge for developing an HIV vaccine. To facilitate immunogen design, it is important to characterize clusters of commonly targeted T-cell epitopes across different HIV clades. To address this, we examined 39 HIV-1 clade C infected indivi...

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Autors principals: Zembe, Lycias, Burgers, Wendy A., Jaspan, Heather B., Bekker, Linda-Gail, Bredell, Helba, Stevens, Gwynneth, Gilmour, Jill, Cox, Josephine H., Fast, Patricia, Hayes, Peter, Vardas, Eftyhia, Williamson, Carolyn, Gray, Clive M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192159/
https://ncbi.nlm.nih.gov/pubmed/22022524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026096
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