A Single Dose of Neuron-Binding Human Monoclonal Antibody Improves Spontaneous Activity in a Murine Model of Demyelination

Our laboratory demonstrated that a natural human serum antibody, sHIgM12, binds to neurons in vitro and promotes neurite outgrowth. We generated a recombinant form, rHIgM12, with identical properties. Intracerebral infection with Theiler's Murine Encephalomyelitis Virus (TMEV) of susceptible mo...

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Detalhes bibliográficos
Main Authors: Denic, Aleksandar, Macura, Slobodan I., Warrington, Arthur E., Pirko, Istvan, Grossardt, Brandon R., Pease, Larry R., Rodriguez, Moses
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192139/
https://ncbi.nlm.nih.gov/pubmed/22022490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026001
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