Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q

Genome-wide association studies (GWAS) in several populations have demonstrated significant association of the IL23R gene with IBD (Crohn's disease (CD) and ulcerative colitis (UC)) and psoriasis, suggesting that perturbation of the IL-23 signaling pathway is relevant to the pathophysiology of...

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Detalhes bibliográficos
Main Authors: Pidasheva, Svetlana, Trifari, Sara, Phillips, Anne, Hackney, Jason A., Ma, Yan, Smith, Ashley, Sohn, Sue J., Spits, Hergen, Little, Randall D., Behrens, Timothy W., Honigberg, Lee, Ghilardi, Nico, Clark, Hilary F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192060/
https://ncbi.nlm.nih.gov/pubmed/22022372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025038
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