Potent suppression of stretch reflex activity after systemic or spinal delivery of Tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia

BACKGROUND: Spasticity and rigidity are serious complications associated with spinal traumatic or ischemic injury. Clinical studies show that Tizanidine (Tiz) is an effective anti-spasticity agent, however, the mechanism of this effect is still not clear. Tiz binds not only to α(2)-adrenoreceptors (...

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Main Authors: Fuchigami, Tatsuya, Kakinohana, Osamu, Hefferan, Michael P., Lukacova, Nadezda, Marsala, Silvia, Sugahara, Kazuhiro, Yaksh, Tony L., Marsala, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192017/
https://ncbi.nlm.nih.gov/pubmed/21871540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2011.08.022
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