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Discovery of Molecular Switches that Modulate Modes of mGlu(5) Pharmacology In Vitro and In Vivo Within a Series of Functionalized, Regioisomeric 2- and 5-(Phenylethynyl) Pyrimidines
This Letter describes the synthesis and SAR of a series of analogs of the mGlu(5) partial antagonist 5-(phenylethynyl)pyrimidine. New molecular switches are identified that modulate the pharmacological activity of the lead compound. Slight structural modifications around the proximal pyrimidine ring...
में बचाया:
| मुख्य लेखकों: | , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2009
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3192011/ https://ncbi.nlm.nih.gov/pubmed/19537763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900654c |
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