Discovery of Molecular Switches that Modulate Modes of mGlu(5) Pharmacology In Vitro and In Vivo Within a Series of Functionalized, Regioisomeric 2- and 5-(Phenylethynyl) Pyrimidines

This Letter describes the synthesis and SAR of a series of analogs of the mGlu(5) partial antagonist 5-(phenylethynyl)pyrimidine. New molecular switches are identified that modulate the pharmacological activity of the lead compound. Slight structural modifications around the proximal pyrimidine ring...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sharma, Sameer, Kedrowski, Jeffrey, Rook, Jerri M., Smith, Randy L., Jones, Carrie K., Rodriguez, Alice L., Conn, P. Jeffrey, Lindsley, Craig W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192011/
https://ncbi.nlm.nih.gov/pubmed/19537763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900654c
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