Tumor Necrosis Factor Alpha Production from CD8(+) T Cells Mediates Oviduct Pathological Sequelae following Primary Genital Chlamydia muridarum Infection

The immunopathogenesis of Chlamydia trachomatis-induced oviduct pathological sequelae is not well understood. Mice genetically deficient in perforin (perforin(−/−) mice) or tumor necrosis factor alpha (TNF-α) production (TNF-α(−/−) mice) displayed comparable vaginal chlamydial clearance rates but si...

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Autori principali: Murthy, Ashlesh K., Li, Weidang, Chaganty, Bharat K. R., Kamalakaran, Sangamithra, Guentzel, M. Neal, Seshu, J., Forsthuber, Thomas G., Zhong, Guangming, Arulanandam, Bernard P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
Soggetti:
Host Response and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191981/
https://ncbi.nlm.nih.gov/pubmed/21536799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05022-11
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