Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use–dependent inhibitor of dopamine synthesis

There is no effective treatment for cocaine addiction despite extensive knowledge of the neurobiology of drug addiction(1–4). Here we show that a selective aldehyde dehydrogenase-2 (ALDH-2) inhibitor, ALDH2i, suppresses cocaine self-administration in rats and prevents cocaine- or cue-induced reinsta...

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Hauptverfasser: Yao, Lina, Fan, Peidong, Arolfo, Maria, Jiang, Zhang, Olive, M Foster, Zablocki, Jeff, Sun, Hai-Ling, Chu, Nancy, Lee, Jeongrim, Kim, Hee-Yong, Leung, Kwan, Shryock, John, Blackburn, Brent, Diamond, Ivan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191463/
https://ncbi.nlm.nih.gov/pubmed/20729865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2200
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