The role of amputation as an outcome measure in cellular therapy for critical limb ischemia: implications for clinical trial design

BACKGROUND: Autologous bone marrow-derived stem cells have been ascribed an important therapeutic role in No-Option Critical limb Ischemia (NO-CLI). One primary endpoint for evaluating NO-CLI therapy is major amputation (AMP), which is usually combined with mortality for AMP-free survival (AFS). Onl...

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Dettagli Bibliografici
Autori principali: Benoit, Eric, O'Donnell, Thomas F, Iafrati, Mark D, Asher, Enrico, Bandyk, Dennis F, Hallett, John W, Lumsden, Alan B, Pearl, Gregory J, Roddy, Sean P, Vijayaraghavan, Krishnaswami, Patel, Amit N
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191337/
https://ncbi.nlm.nih.gov/pubmed/21951607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-165
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