Activation of the Bumetanide-sensitive Na(+),K(+),2Cl(−) Cotransporter (NKCC2) Is Facilitated by Tamm-Horsfall Protein in a Chloride-sensitive Manner

Active transport of NaCl across thick ascending limb (TAL) epithelium is accomplished by Na(+),K(+),2Cl(−) cotransporter (NKCC2). The activity of NKCC2 is determined by vasopressin (AVP) or intracellular chloride concentration and includes its amino-terminal phosphorylation. Co-expressed Tamm-Horsfa...

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Detalhes bibliográficos
Main Authors: Mutig, Kerim, Kahl, Thomas, Saritas, Turgay, Godes, Michael, Persson, Pontus, Bates, James, Raffi, Hajamohideen, Rampoldi, Luca, Uchida, Shinichi, Hille, Carsten, Dosche, Carsten, Kumar, Satish, Castañeda-Bueno, Maria, Gamba, Gerardo, Bachmann, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191059/
https://ncbi.nlm.nih.gov/pubmed/21737451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.222968
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