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HIV-1 Nucleocapsid Protein Increases Strand Transfer Recombination by Promoting Dimeric G-quartet Formation

A preferred site for HIV-1 recombination was identified in vivo and in vitro surrounding the beginning of the HIV-1 gag gene. This G-rich gag hotspot for recombination contains three evenly spaced G-runs that stalled reverse transcriptase. Disruption of the G-runs suppressed both the associated paus...

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Detalhes bibliográficos
Main Authors: Shen, Wen, Gorelick, Robert J., Bambara, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191025/
https://ncbi.nlm.nih.gov/pubmed/21737842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.262352
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