Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species

Expression of the STAT3 transcription factor in the heart is cardioprotective and decreases the levels of reactive oxygen species. Recent studies indicate that a pool of STAT3 resides in the mitochondria where it is necessary for the maximal activity of complexes I and II of the electron transport c...

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Autores principales: Szczepanek, Karol, Chen, Qun, Derecka, Marta, Salloum, Fadi N., Zhang, Qifang, Szelag, Magdalena, Cichy, Joanna, Kukreja, Rakesh C., Dulak, Jozef, Lesnefsky, Edward J., Larner, Andrew C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191002/
https://ncbi.nlm.nih.gov/pubmed/21715323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226209
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