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Kinetic and Chemical Mechanisms of Homocitrate Synthase from Thermus thermophilus
The homocitrate synthase from Thermus thermophilus (TtHCS) is a metal-activated enzyme with either Mg(2+) or Mn(2+) capable of serving as the divalent cation. The enzyme exhibits a sequential kinetic mechanism. The mechanism is steady state ordered with α-ketoglutarate (α-Kg) binding prior to acetyl...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3190748/ https://ncbi.nlm.nih.gov/pubmed/21733842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.246355 |
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