Modulation of CCAAT/Enhancer Binding Protein Homologous Protein (CHOP)-dependent DR5 Expression by Nelfinavir Sensitizes Glioblastoma Multiforme Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)

Human glioblastoma multiforme cells demonstrate varying levels of sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Endoplasmic reticulum (ER) stress has been shown to trigger cell death through apoptosis. We therefore pursued a strategy of integrating...

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Detalhes bibliográficos
Main Authors: Tian, Xiaobing, Ye, Jiangbin, Alonso-Basanta, Michelle, Hahn, Stephen M., Koumenis, Constantinos, Dorsey, Jay F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190746/
https://ncbi.nlm.nih.gov/pubmed/21697087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.197665
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