Essential Role of Endocytosis of the Type II Transmembrane Serine Protease TMPRSS6 in Regulating Its Functionality

The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism. Upstream of the hepcidin-regulated signaling pathway, TMPRSS6 cleaves its target substrate he...

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Bibliographic Details
Main Authors: Béliveau, François, Brulé, Cédric, Désilets, Antoine, Zimmerman, Brandon, Laporte, Stéphane A., Lavoie, Christine L., Leduc, Richard
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190711/
https://ncbi.nlm.nih.gov/pubmed/21724843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.223461
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