Safety Evaluation of EXPAREL (DepoFoam Bupivacaine) Administered by Repeated Subcutaneous Injection in Rabbits and Dogs: Species Comparison

EXPAREL (bupivacaine extended-release liposome injection), DepoFoam bupivacaine, is in development for prolonged postsurgical analgesia. Repeat-dose toxicity studies were conducted in rabbits and dogs to compare the potential local and systemic toxicities of EXPAREL and bupivacaine HCl (Bsol), and t...

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Detalhes bibliográficos
Main Authors: Richard, Brigitte M., Rickert, Douglas E., Newton, Paul E., Ott, Laura R., Haan, Dean, Brubaker, Abram N., Cole, Phaedra I., Ross, Paul E., Rebelatto, Marlon C., Nelson, Keith G.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189577/
https://ncbi.nlm.nih.gov/pubmed/22013534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/467429
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