E339…R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors

The nucleoprotein (NP) of the influenza virus exists as trimers, and its tail-loop binding pocket has been suggested as a potential target for antiinfluenza therapeutics. The possibility of NP as a drug target was validated by the recent reports that nucleozin and its analogs can inhibit viral repli...

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Autores principales: Shen, Yu-Fang, Chen, Yu-Hou, Chu, Shao-Ying, Lin, Meng-I, Hsu, Hua-Ting, Wu, Pei-Yu, Wu, Chao-Jung, Liu, Hui-Wen, Lin, Fu-Yang, Lin, Gialih, Hsu, Pang-Hung, Yang, An-Suei, Cheng, Yih-Shyun E., Wu, Ying-Ta, Wong, Chi-Huey, Tsai, Ming-Daw
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
Physical Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189076/
https://ncbi.nlm.nih.gov/pubmed/21930946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113107108
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