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Sequence-specific binding of echinomycin to DNA: evidence for conformational changes affecting flanking sequences.

The technique of DNAase I footprinting has been used to investigate preferred binding sites for echinomycin on a 160-base-pair DNA fragment from E. coli containing the tyr T promoter sequence. Six binding sites have been precisely located in the sequence; a seventh has been partially identified. The...

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Bibliographic Details
Main Authors: Low, C M, Drew, H R, Waring, M J
Format: Artigo
Language:Inglês
Published: 1984
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC318885/
https://ncbi.nlm.nih.gov/pubmed/6204275
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