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Presenilin-2 modulation of ER-mitochondria interactions: FAD mutations, mechanisms and pathological consequences

Presenilin (PS) mutations are the main cause of Familial Alzheimer's Disease (FAD) and have been demonstrated to cause an imbalance of intracellular Ca(2+) homeostasis. Though PS1 and 2 are generally considered to behave similarly in terms of their effects on Ca(2+) handling, we have recently d...

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Main Authors: Zampese, Enrico, Fasolato, Cristina, Pozzan, Tullio, Pizzo, Paola
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187908/
https://ncbi.nlm.nih.gov/pubmed/21980580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cib.4.3.15160
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