Characterization of Structural Features and Diversity of Variable-Region Determinants of Related Quaternary Epitopes Recognized by Human and Rhesus Macaque Monoclonal Antibodies Possessing Unusually Potent Neutralizing Activities

A series of potently neutralizing monoclonal antibodies (MAbs) that target quaternary epitopes on the native Env trimer have recently been described. A common feature shared by these antibodies is the critical involvement of sites in both the V2 and V3 variable domains in antibody recognition. In th...

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Autores principales: Krachmarov, Chavdar, Lai, Zhong, Honnen, William J., Salomon, Aidy, Gorny, Miroslaw K., Zolla-Pazner, Susan, Robinson, James, Pinter, Abraham
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2011
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187505/
https://ncbi.nlm.nih.gov/pubmed/21835798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00365-11
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