Klf1 Affects DNase II-Alpha Expression in the Central Macrophage of a Fetal Liver Erythroblastic Island: a Non-Cell-Autonomous Role in Definitive Erythropoiesis

A key regulatory gene in definitive erythropoiesis is the erythroid Kruppel-like factor (Eklf or Klf1). Klf1 knockout (KO) mice die in utero due to severe anemia, while residual circulating red blood cells retain their nuclei. Dnase2a is another critical gene in definitive erythropoiesis. Dnase2a KO...

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Auteurs principaux: Porcu, Susanna, Manchinu, Maria F., Marongiu, Maria F., Sogos, Valeria, Poddie, Daniela, Asunis, Isadora, Porcu, Loredana, Marini, Maria G., Moi, Paolo, Cao, Antonio, Grosveld, Frank, Ristaldi, Maria S.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2011
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187365/
https://ncbi.nlm.nih.gov/pubmed/21807894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05532-11
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