The Biofilm Inhibitor Carolacton Disturbs Membrane Integrity and Cell Division of Streptococcus mutans through the Serine/Threonine Protein Kinase PknB

Carolacton, a secondary metabolite isolated from the myxobacterium Sorangium cellulosum, disturbs Streptococcus mutans biofilm viability at nanomolar concentrations. Here we show that carolacton causes leakage of cytoplasmic content (DNA and proteins) in growing cells at low pH and provide quantitat...

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Autors principals: Reck, Michael, Rutz, Katrin, Kunze, Brigitte, Tomasch, Jürgen, Surapaneni, Subhash Kumar, Schulz, Stefan, Wagner-Döbler, Irene
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187222/
https://ncbi.nlm.nih.gov/pubmed/21840978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.05424-11
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