The Biofilm Inhibitor Carolacton Disturbs Membrane Integrity and Cell Division of Streptococcus mutans through the Serine/Threonine Protein Kinase PknB

Carolacton, a secondary metabolite isolated from the myxobacterium Sorangium cellulosum, disturbs Streptococcus mutans biofilm viability at nanomolar concentrations. Here we show that carolacton causes leakage of cytoplasmic content (DNA and proteins) in growing cells at low pH and provide quantitat...

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Autores principales: Reck, Michael, Rutz, Katrin, Kunze, Brigitte, Tomasch, Jürgen, Surapaneni, Subhash Kumar, Schulz, Stefan, Wagner-Döbler, Irene
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2011
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187222/
https://ncbi.nlm.nih.gov/pubmed/21840978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.05424-11
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