Efficacy of Oral E1210, a New Broad-Spectrum Antifungal with a Novel Mechanism of Action, in Murine Models of Candidiasis, Aspergillosis, and Fusariosis

E1210 is a first-in-class, broad-spectrum antifungal with a novel mechanism of action—inhibition of fungal glycosylphosphatidylinositol biosynthesis. In this study, the efficacies of E1210 and reference antifungals were evaluated in murine models of oropharyngeal and disseminated candidiasis, pulmon...

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Detalhes bibliográficos
Main Authors: Hata, Katsura, Horii, Takaaki, Miyazaki, Mamiko, Watanabe, Nao-aki, Okubo, Miyuki, Sonoda, Jiro, Nakamoto, Kazutaka, Tanaka, Keigo, Shirotori, Syuji, Murai, Norio, Inoue, Satoshi, Matsukura, Masayuki, Abe, Shinya, Yoshimatsu, Kentaro, Asada, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187015/
https://ncbi.nlm.nih.gov/pubmed/21788462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00366-11
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