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Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents.

The C-8 position of deoxyguanosine (dGuo) was hydroxylated by ascorbic acid in the presence of oxygen (O2) in 0.1 M phosphate buffer (pH 6.8) at 37 degrees C. Addition of hydrogen peroxide (H2O2) remarkably enhanced this hydroxylation. The Udenfriend system [ascorbic acid, FeII, ethylenediaminetetra...

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Detalhes bibliográficos
Main Authors: Kasai, H, Nishimura, S
Formato: Artigo
Idioma:Inglês
Publicado em: 1984
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC318646/
https://ncbi.nlm.nih.gov/pubmed/6701097
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