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Pharmacogenomics of bortezomib test-dosing identifies hyperexpression of proteasome genes, especially PSMD4, as novel high-risk feature in myeloma treated with Total Therapy 3
Gene expression profiling (GEP) of purified plasma cells 48 hours after thalidomide and dexamethasone test doses showed these agents' mechanisms of action and provided prognostic information for untreated myeloma patients on Total Therapy 2 (TT2). Bortezomib was added in Total Therapy 3 (TT3),...
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Main Authors: | , , , , , , , , , , , , , , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
American Society of Hematology
2011
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3186329/ https://ncbi.nlm.nih.gov/pubmed/21628408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-328252 |
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