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Pharmacogenomics of bortezomib test-dosing identifies hyperexpression of proteasome genes, especially PSMD4, as novel high-risk feature in myeloma treated with Total Therapy 3

Gene expression profiling (GEP) of purified plasma cells 48 hours after thalidomide and dexamethasone test doses showed these agents' mechanisms of action and provided prognostic information for untreated myeloma patients on Total Therapy 2 (TT2). Bortezomib was added in Total Therapy 3 (TT3),...

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Bibliografiske detaljer
Main Authors: Shaughnessy, John D., Qu, Pingping, Usmani, Saad, Heuck, Christoph J., Zhang, Qing, Zhou, Yiming, Tian, Erming, Hanamura, Ichiro, van Rhee, Frits, Anaissie, Elias, Epstein, Joshua, Nair, Bijay, Stephens, Owen, Williams, Ryan, Waheed, Sarah, Alsayed, Yazan, Crowley, John, Barlogie, Bart
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186329/
https://ncbi.nlm.nih.gov/pubmed/21628408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-328252
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