Prognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy

BACKGROUND: Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established. DESIGN AND METHODS: We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in patients treated with all-trans retinoic acid and...

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Autori principali: Barragán, Eva, Montesinos, Pau, Camos, Mireia, González, Marcos, Calasanz, Maria J., Román-Gómez, José, Gómez-Casares, Maria T., Ayala, Rosa, López, Javier, Fuster, Óscar, Colomer, Dolors, Chillón, Carmen, Larrayoz, María J., Sánchez-Godoy, Pedro, González-Campos, José, Manso, Félix, Amador, Maria L., Vellenga, Edo, Lowenberg, Bob, Sanz, Miguel A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2011
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186308/
https://ncbi.nlm.nih.gov/pubmed/21685470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.044933
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