DZNep Is a Global Histone Methylation Inhibitor that Reactivates Developmental Genes Not Silenced by DNA Methylation

DNA methylation, histone modifications, and nucleosomal occupancy collaborate to cause silencing of tumor-related genes in cancer. The development of drugs that target these processes is therefore important for cancer therapy. Inhibitors of DNA methylation and histone deacetylation have been approve...

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Bibliographic Details
Main Authors: Miranda, Tina Branscombe, Cortez, Connie C., Yoo, Christine B., Liang, Gangning, Abe, Masanobu, Kelly, Theresa K., Marquez, Victor E., Jones, Peter A.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186068/
https://ncbi.nlm.nih.gov/pubmed/19509260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0013
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