XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibility

Oxidative DNA damage plays a role in disease development and the aging process. A prominent participant in orchestrating the repair of oxidative DNA damage, particularly single-strand breaks, is the scaffold protein XRCC1. A series of chronological and biological aging parameters in XRCC1 heterozygo...

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Autors principals: McNeill, Daniel R., Lin, Ping-Chang, Miller, Marshall G., Pistell, Paul J., de Souza-Pinto, Nadja C., Fishbein, Kenneth W., Spencer, Richard G., Liu, Yie, Pettan-Brewer, Christina, Ladiges, Warren C., Wilson, David M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185405/
https://ncbi.nlm.nih.gov/pubmed/21737425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr280
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