Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase

Exposure of yeast to high osmolarity induces a transient activation of the Hog1 stress-activated protein kinase (SAPK), which is required for cell survival under these conditions. However, sustained activation of the SAPK results in a severe growth defect. We found that prolonged SAPK activation lea...

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Detalhes bibliográficos
Main Authors: Vendrell, Alexandre, Martínez-Pastor, Mar, González-Novo, Alberto, Pascual-Ahuir, Amparo, Sinclair, David A, Proft, Markus, Posas, Francesc
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185340/
https://ncbi.nlm.nih.gov/pubmed/21836634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.154
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