Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails

Degradation of nuclear DNA is a hallmark of programmed cell death. Epidermal keratinocytes die in the course of cornification to function as the dead building blocks of the cornified layer of the epidermis, nails and hair. Here we investigated the mechanism and physiological function of DNA degradat...

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Hauptverfasser: Fischer, Heinz, Szabo, Sandra, Scherz, Jennifer, Jaeger, Karin, Rossiter, Heidemarie, Buchberger, Maria, Ghannadan, Minoo, Hermann, Marcela, Theussl, Hans-Christian, Tobin, Desmond J., Wagner, Erwin F., Tschachler, Erwin, Eckhart, Leopold
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185332/
https://ncbi.nlm.nih.gov/pubmed/21307874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2011.13
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