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Effect of Sulindac Sulfide on Metallohydrolases in the Human Colon Cancer Cell Line HT-29

Matrix metalloproteinase 7 (MMP7), a metallohydrolase involved in the development of several cancers, is downregulated in the Apc(Min/+) colon cancer mouse model following sulindac treatment. To determine whether this effect is relevant to the human condition, HT-29 human colon cancer cells were tre...

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Autores principales: Guillen-Ahlers, Hector, Tan, Jiangning, Castellino, Francis J., Ploplis, Victoria A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185020/
https://ncbi.nlm.nih.gov/pubmed/21991341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025725
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