Targeting the Heat Shock Protein 90 Dimer with Dimeric Inhibitors

The design, synthesis and biological evaluation of conformationally constrained coumermycin A1 analogues are reported. Compounds were evaluated against both breast cancer (SKBr3 and MCF7) and prostate cancer (PC3mm2, A549 and HT29) cell lines. Non-noviosylated coumermycin A1 analogues that manifest...

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Hauptverfasser: Kusuma, Bhaskar Reddy, Peterson, Laura B., Zhao, Huiping, Vielhauer, George, Holzbeierlein, Jeffrey, Blagg, Brian S. J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184553/
https://ncbi.nlm.nih.gov/pubmed/21861487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200553w
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