Bone Marrow Suppression by c-Kit Blockade Enhances Tumor Growth of Colorectal Metastases through the Action of Stromal Cell-Derived Factor-1

Background. Mobilization of c-Kit(+) hematopoietic cells (HCs) contributes to tumor vascularization. Whereas survival and proliferation of HCs are regulated by binding of the stem cell factor to its receptor c-Kit, migration of HCs is directed by stromal cell-derived factor (SDF)-1. Therefore, targe...

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Main Authors: Rupertus, Kathrin, Haberl, Gudrun C. Y., Scheuer, Claudia, Menger, Michael D., Schilling, Martin K., Kollmar, Otto
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184505/
https://ncbi.nlm.nih.gov/pubmed/21977032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/196957
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