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Aortic Valve Cyclic Stretch Causes Increased Remodeling Activity and Enhanced Serotonin Receptor Responsiveness

BACKGROUND: Increased serotonin(5HT) receptor(5HTR) signaling has been associated with cardiac valvulopathy. Prior cell culture studies of 5HTR signaling in heart valve interstitial cells have provided mechanistic insights concerning only static conditions. We investigated the hypothesis that aortic...

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Autori principali: Balachandran, Kartik, Bakay, Marina A., Connolly, Jeanne M., Zhang, Xuemei, Yoganathan, Ajit P., Levy, Robert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184405/
https://ncbi.nlm.nih.gov/pubmed/21718840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2011.03.084
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