Hepatic Differentiation of Murine Disease-Specific Induced Pluripotent Stem Cells Allows Disease Modelling In Vitro

Direct reprogramming of somatic cells into pluripotent cells by retrovirus-mediated expression of OCT4, SOX2, KLF4, and C-MYC is a promising approach to derive disease-specific induced pluripotent stem cells (iPSCs). In this study, we focused on three murine models for metabolic liver disorders: the...

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Main Authors: Eggenschwiler, Reto, Loya, Komal, Sgodda, Malte, André, Francoise, Cantz, Tobias
Format: Artigo
Jezik:Inglês
Izdano: SAGE-Hindawi Access to Research 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184399/
https://ncbi.nlm.nih.gov/pubmed/21977043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/924782
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