Genetic Variants of the Non-homologous End Joining Gene LIG4 and Severe Radiation Pneumonitis in Non-small Cell Lung Cancer Patients Treated with Definitive Radiotherapy

BACKGROUND: Non-homologous end joining (NHEJ) is a pathway that repairs DNA double-strand breaks (DSBs) to maintain genomic stability in response to irradiation. We hypothesized that single nucleotide polymorphisms (SNPs) in NHEJ repair genes may affect clinical outcomes among non-small cell lung ca...

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Bibliographic Details
Main Authors: Yin, Ming, Liao, Zhongxing, Liu, Zhensheng, Wang, Li-E, O'Reilly, Michael, Gomez, Daniel, Li, Minghuan, Komaki, Ritsuko, Wei, Qingyi
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184314/
https://ncbi.nlm.nih.gov/pubmed/21717429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.26214
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