TGF-β Regulates DNA Methyltransferase Expression in Prostate Cancer, Correlates with Aggressive Capabilities, and Predicts Disease Recurrence

BACKGROUND: DNA methyltransferase (DNMT) is one of the major factors mediating the methylation of cancer related genes such as TGF-β receptors (TβRs). This in turn may result in a loss of sensitivity to physiologic levels of TGF-β in aggressive prostate cancer (CaP). The specific mechanisms of DNMT&...

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Main Authors: Zhang, Qiang, Chen, Lin, Helfand, Brian T., Jang, Thomas L., Sharma, Vidit, Kozlowski, James, Kuzel, Timothy Michael, Zhu, Lihua J., Yang, Ximing J., Javonovic, Borko, Guo, Yinglu, Lonning, Scott, Harper, Jay, Teicher, Beverly A., Brendler, Charles, Yu, Nengwang, Catalona, William J., Lee, Chung
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2011
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184137/
https://ncbi.nlm.nih.gov/pubmed/21980391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025168
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