Intra-arterial administration of recombinant tissue-type plasminogen activator (rt-PA) causes more intracranial bleeding than does intravenous rt-PA in a transient rat middle cerebral artery occlusion model

BACKGROUND: Intra-arterial (IA) administration of rt-PA for ischemic stroke has the potential for greater thrombolytic efficacy, especially for a large thrombus in the M1 or M2 segment of the middle cerebral artery (MCA). Intracranial hemorrhage (ICH) is a concern with IA or intravenous (IV) adminis...

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Detalhes bibliográficos
Main Authors: Crumrine, R Christian, Marder, Victor J, Taylor, G McLeod, LaManna, Joseph C, Tsipis, Constantinos P, Scuderi, Philip, Petteway, Stephen R, Arora, Vikram
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184064/
https://ncbi.nlm.nih.gov/pubmed/21933438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-7378-3-10
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