The TAg-RB Murine Retinoblastoma Cell of Origin Has Immunohistochemical Features of Differentiated Müller Glia with Progenitor Properties

PURPOSE. Human retinoblastoma arises from an undefined developing retinal cell after inactivation of RB1. This is emulated in a murine retinoblastoma model by inactivation of pRB by retinal-specific expression of simian virus 40 large T-antigen (TAg-RB). Some mutational events after RB1 loss in huma...

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Hauptverfasser: Pajovic, Sanja, Corson, Timothy W., Spencer, Clarellen, Dimaras, Helen, Orlic-Milacic, Marija, Marchong, Mellone N., To, Kwong-Him, Thériault, Brigitte, Auspitz, Mark, Gallie, Brenda L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Association for Research in Vision and Ophthalmology, Inc. 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183982/
https://ncbi.nlm.nih.gov/pubmed/21862643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-7989
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